A key connection between gut microbiome and experimentally-induced diabetes by Adam Burrack, PhD Readers of our series will be familiar with the concept of the gut microbiome. In short, this term refers to the observation that the number of bacteria in our intestines outnumbers the human cells of our bodies by a factor of 10-to-1. […]
Saturday Morning Research Review – August 20, 2016
Liver glycogen level determines counter-regulatory hormone response to low blood sugar levels by Adam Burrack, PhD Our readers – especially those with type 1 diabetes who have trained for and competed in races – will be aware: glucose is the primary source of fuel during exercise. In addition, you are probably aware that liver glycogen […]
Saturday Morning Research Review – August 6, 2016
Cardiorespiratory Fitness as a Predictor of Type 2 Diabetes By Daniel Schneider In case anyone was still not convinced, here’s another study that we can add to the long pile of reasons to exercise. In this longitudinal study (done over a long period of time), thousands of people took a stress test to test their fitness […]
Saturday Morning Research Review – July 30, 2016
The relationship of viral infection and autoimmunity by Adam Burrack, PhD Readers of our blog will be familiar with the concept of pancreas-tropic viruses accelerating beta cell destruction. The most extreme version of this concept is fulminant diabetes, which I have described previously. The general idea is that a viral infection in the pancreas, promotes […]
Saturday Morning Research Review – July 23, 2016
Reversion of beta cell autoimmunity and rate of progression from autoantibodies to T1D by Adam Burrack, PhD As I’ve described previously in our “science of type 1 diabetes” series, the TEDDY and DAISY studies are large cohort, longitudinal studies designed to test the genetic and environmental factors precipitating development of autoimmunity against beta cells and subsequent […]
Saturday Morning Research Review – July 16, 2016
Minimal intervals to improve insulin sensitivity and aerobic capacity by Adam Burrack, PhD No time to exercise, you say? Can’t spare the time from your busy schedule but still want the key benefits of enhanced insulin sensitivity and enhanced mitochondrial density? Have you signed up for a 10K but haven’t been able to do […]
Saturday Morning Research Review – July 9, 2016
Nocturnal hypoglycemia is surprisingly common in children with type 1 diabetes by Adam Burrack, PhD As we have previously discussed, a major driving motivation behind the development of so-called closed-loop insulin pump and continuous glucose monitor systems is to avoid low blood sugars overnight. This problem, nocturnal hypoglycemia and potentially spending hours at a time […]
Saturday Morning Research Review – July 2, 2016
Promising results of phase 3 clinical trial of islet transplantation to treat hypoglycemia unawareness by Adam Burrack, PhD I’ve previously given an over-view of the state-of-the-art in islet transplantation in my post about the work of James Shapiro and the Edmonton Protocol for immune suppression. In short, prior to the development of strong but non-toxic methods to […]
Saturday Morning Research Review – June 25, 2016
Effects of intense exercise on insulin release and glucose regulation by Adam Burrack, PhD In our “exercise with type 1 diabetes” blog thread, I’ve previously described some of the anti-inflammatory benefits of aerobic exercise for people with type 1 diabetes. As it relates to maximal exercise intensity, the more oxygen we consume at maximum running/cycling […]
Saturday Morning Research Review – June 18, 2016
Runner’s World asks, How Do You Maximize Your Mitochondria? by Daniel Schneider Just 2 weeks ago we pointed to research suggesting that improved mitochondrial function might improve blood glucose management. Improving the quantity and function of the mitochondria is key to endurance athletic performance, but also might be helpful in metabolizing sugar. We used the analogy […]