Benaroya Institute, Diabetes Management Technology, Carla Greenbaum By Josh Boyer, MSc One issue that scientists have long struggled with is communication between disciplines. I am an immunologist at UCSD studying lymphocyte trafficking and my main passion is the autoimmune pathogenesis behind type 1 diabetes. While I have long studied diabetes, I don’t often read articles […]
Category Archives: Research Review
Saturday Morning Research Review – April 1, 2017
T follicular helper cells facilitate autoantibody production and subsequent beta cell destruction by Adam Burrack, PhD In today’s post, I’m going to add to our series describing the process of beta cell destruction leading to type 1 diabetes (T1D) by describing the germinal center reaction. This process, which occurs primarily in lymph nodes but can occur […]
Saturday Morning Research Review – March 25, 2017
If at first you don’t succeed, try another training plan by Adam Burrack, PhD At YOUglycemia, we advocate an (aerobically) active lifestyle as a key component of diabetes management. We personally span the range from racing the mile (Adam) to the Ironman (Gillian). Aerobic exercise – by which most people would mean moderate intensity, longer […]
Saturday Morning Research Review – March 18, 2017
Diet influences gut bacteria, gut bacteria influence immune response to diet by Adam Burrack, PhD In today’s post I will describe a developing body of literature from which evidence is mounting that what we eat influences how our immune system responds to not only what we eat, but also to the bacteria living in our […]
Saturday Morning Research Review – March 11, 2017
The “race” to develop the first FDA-approved insulin dosing algorithm by Adam Burrack, PhD In the vast majority of our blogs, I’ve focused on the fundamental problem underlying type 1 diabetes (T1D), destruction of insulin-producing beta cells by the immune system. I am fascinated by the biology underpinning how the immune system mis-identifies beta cells […]
Saturday Morning Research Review – March 4, 2017
Key differences between type 1 diabetes and type 2 diabetes: autoantibodies and inflammation by Adam Burrack, PhD It’s a persistent question when comparing type 1 diabetes and type 2 diabetes: they require the same treatment – insulin injections – so how similar are the disease processes leading to beta cell death? In general this is […]
Saturday Morning Research Review – February 11, 2017
Engineered beta cells may be a fourth path to restored euglycemia for diabetic patients by Adam Burrack, PhD In our “science of diabetes” series, I’ve previously described a couple of neat “engineering solutions” to insulin infusion and diabetes management. One of these was “smart insulin” about Danny Chou and the smart insulin initiative by JDRF. The […]
Saturday Morning Research Review – February 4, 2017
An additional hybrid insulin peptide as target of autoreactive T cells by Adam Burrack, PhD Readers of our “science of diabetes” blog will remember a news story about a year ago, in which researchers at the Barbara Davis Center in Denver, Colorado and in Australia collaborated to demonstrated the clinical relevance of so-called hybrid insulin […]
Saturday Morning Research Review – January 21, 2017
Defects in development of regulatory T cells promote autoimmune disease by Adam Burrack, PhD Biology is a confusing beast sometimes. In particular the immune system. In particular the checks and balances between different branches of the immune system, each with different goals. Effector T cells protect the organism from exterior threats – potentially at the […]
Saturday Morning Research Review – January 14, 2017
Finding autoreactive T cells within type 1 diabetic pancreas samples by Adam Burrack, PhD We continue our series of descriptions of research output of the Human Islet Research Network. As a brief reminder, this consortium of NIH-funded researchers are working to develop methods to delay beta cell death, manipulate the immune system to prevent beta […]