Saturday Morning Research Review – March 10, 2018

Presence and activation status of insulin-specific T cells is related to insulin autoantibodies by Adam Burrack, PhD In today͛s edition, I will describe a project that I was involved with, in a minor role. It has been an on-going debate in the field whether immune responses against the insulin molecule itself are the driving force […]

Saturday Morning Research Review – February 3, 2018

Gran Fondos and delayed hypoglycemia by Adam Burrack, PhD I had the opportunity last summer to race in two duathlons and two longer-distance cycling events. In this post I͛ll share how my diabetes management worked – or didn͛t work as the case may be – for these events. I raced the regional ͚ championship͛ race […]

Saturday Morning Research Review – December 30, 2017

Advancing our understanding of transplant recognition by the immune system ​by Adam Burrack, PhD Today I have the privilege of describing research I performed. A fundamental problem facing scientists seeking to cure type 1 diabetes (T1D) through beta cell replacement is the immune response to “foreign” tissues following transplantation. Ironically, the genes with the highest […]

Saturday Morning Research Review – November 25, 2017

Position Statement on Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes by Daniel Schneider, MSc When I head to the endocrinologist to check in with my doctor, I’m usually curious and waiting for the results of that benchmark test by which we are all sometimes guilty of celebrating or harshly judging ourselves. […]

Saturday Morning Research Review – August 12, 2017

Glucagon dynamics during exercise with type 1 diabetes                by Adam Burrack, PhD Previously in our series, we have described the exercise science of maximal performance in terms of oxygen consumption (basically 2-mile race pace) and how imperfect, artificial, control of insulin levels during exercise may negatively affect exercise performance. Too much insulin in the circulation […]

Saturday Morning Research Review – June 24, 2017

Dietary strategies for management of Type 1 Diabetes – The Paleo Diet by Rachel Fenske, BS I am excited to bring you my second post in a special series for YOUglycemia regarding the complex interactions of type 1 diabetes pathophysiology, diet, and exercise. Today, I will be reviewing what’s been termed the “Paleo” diet, or […]

Saturday Morning Research Review – May 13, 2017

Genetic and cultural differences in T1D risk and management by Adam Burrack, PhD In this edition of our “science of diabetes” blog series, I will delve a little more deeply into the genetics of type 1 diabetes (T1D) HLA risk alleles. HLA is immunology short-hand for ‘human leukocyte antigen’ and is the molecule through which […]

Saturday Morning Research Review – May 6, 2017

Looking within human pancreas samples for T cells responsible for beta cell destruction                   by Adam Burrack, PhD Sally Kent, member of nPOD and HIRN, has recently published a couple of studies investigating T cells within pancreatic islets. Dr Kent’s laboratory is located at the University of Massachusetts medical school. In addition, Dr Kent was […]

Saturday Morning Research Review – April 29, 2017

Resident memory T cells within pancreatic islets after T1D onset by Adam Burrack, PhD A fundamental problem with islet replacement therapy as a cure for type 1 diabetes is the presence of immune cells that will specifically target and destroy insulin-producing beta cells. These cells are descendants of the T cells that destroyed beta cells […]

Saturday Morning Research Review – April 22, 2017

Update on closed-loop insulin pump algorithms by Josh Boyer, MS In this piece I will go over what in my opinion is one of the greatest recent developments in diabetes therapy, closed-loop systems.  With the release of the Minimed 670G system, I would guess that many people are aware of these devices and curious to […]