Presence and activation status of insulin-specific T cells is related to insulin autoantibodies by Adam Burrack, PhD In today͛s edition, I will describe a project that I was involved with, in a minor role. It has been an on-going debate in the field whether immune responses against the insulin molecule itself are the driving force […]

Gran Fondos and delayed hypoglycemia by Adam Burrack, PhD I had the opportunity last summer to race in two duathlons and two longer-distance cycling events. In this post I͛ll share how my diabetes management worked – or didn͛t work as the case may be – for these events. I raced the regional ͚ championship͛ race […]

Advancing our understanding of transplant recognition by the immune system ​by Adam Burrack, PhD Today I have the privilege of describing research I performed. A fundamental problem facing scientists seeking to cure type 1 diabetes (T1D) through beta cell replacement is the immune response to “foreign” tissues following transplantation. Ironically, the genes with the highest […]

Position Statement on Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes by Daniel Schneider, MSc When I head to the endocrinologist to check in with my doctor, I’m usually curious and waiting for the results of that benchmark test by which we are all sometimes guilty of celebrating or harshly judging ourselves. […]

Dietary strategies for management of Type 1 Diabetes – The Paleo Diet by Rachel Fenske, BS I am excited to bring you my second post in a special series for YOUglycemia regarding the complex interactions of type 1 diabetes pathophysiology, diet, and exercise. Today, I will be reviewing what’s been termed the “Paleo” diet, or […]

Genetic and cultural differences in T1D risk and management by Adam Burrack, PhD In this edition of our “science of diabetes” blog series, I will delve a little more deeply into the genetics of type 1 diabetes (T1D) HLA risk alleles. HLA is immunology short-hand for ‘human leukocyte antigen’ and is the molecule through which […]

Looking within human pancreas samples for T cells responsible for beta cell destruction                   by Adam Burrack, PhD Sally Kent, member of nPOD and HIRN, has recently published a couple of studies investigating T cells within pancreatic islets. Dr Kent’s laboratory is located at the University of Massachusetts medical school. In addition, Dr Kent was […]

Resident memory T cells within pancreatic islets after T1D onset by Adam Burrack, PhD A fundamental problem with islet replacement therapy as a cure for type 1 diabetes is the presence of immune cells that will specifically target and destroy insulin-producing beta cells. These cells are descendants of the T cells that destroyed beta cells […]

Update on closed-loop insulin pump algorithms by Josh Boyer, MS In this piece I will go over what in my opinion is one of the greatest recent developments in diabetes therapy, closed-loop systems.  With the release of the Minimed 670G system, I would guess that many people are aware of these devices and curious to […]