Saturday Morning Research Review – March 4, 2017

Key differences between type 1 diabetes and type 2 diabetes: autoantibodies and inflammation by Adam Burrack, PhD It’s a persistent question when comparing type 1 diabetes and type 2 diabetes: they require the same treatment – insulin injections – so how similar are the disease processes leading to beta cell death? In general this is […]

Saturday Morning Research Review – February 25, 2017

Skeletal muscle regenerative capacity may be decreased with type 1 diabetes By Adam Burrack, PhD, and Daniel Schneider, MSc A recent article in Diabetes describes an interesting finding about skeletal muscle in insulin-deficient diabetic mice and people with type 1 diabetes. These findings may have direct implications for how people with type 1 diabetes may […]

Saturday Morning Research Review – February 11, 2017

Engineered beta cells may be a fourth path to restored euglycemia for diabetic patients by Adam Burrack, PhD In our “science of diabetes” series, I’ve previously described a couple of neat “engineering solutions” to insulin infusion and diabetes management. One of these was “smart insulin” about Danny Chou and the smart insulin initiative by JDRF. The […]

Saturday Morning Research Review – February 4, 2017

An additional hybrid insulin peptide as target of autoreactive T cells by Adam Burrack, PhD Readers of our “science of diabetes” blog will remember a news story about a year ago, in which researchers at the Barbara Davis Center in Denver, Colorado and in Australia collaborated to demonstrated the clinical relevance of so-called hybrid insulin […]

Saturday Morning Research Review – January 28, 2017

Inflammation promotes intra-pancreas neuron signaling which promote Th17 cells which promote beta cell destruction by Adam Burrack, PhD In a previous post about zonulin, I described how our diet influences gut permeability and may play a role in gut-directed autoimmunity. In that post I described the hypothesis that our diet influences the immune system’s response […]

Saturday Morning Research Review – January 21, 2017

Defects in development of regulatory T cells promote autoimmune disease by Adam Burrack, PhD Biology is a confusing beast sometimes. In particular the immune system. In particular the checks and balances between different branches of the immune system, each with different goals. Effector T cells protect the organism from exterior threats – potentially at the […]

Saturday Morning Research Review – January 14, 2017

Finding autoreactive T cells within type 1 diabetic pancreas samples by Adam Burrack, PhD We continue our series of descriptions of research output of the Human Islet Research Network. As a brief reminder, this consortium of NIH-funded researchers are working to develop methods to delay beta cell death, manipulate the immune system to prevent beta […]

Saturday Morning Research Review – January 7, 2017

Pancreatic islet transplant survival promoted by co-transfer of immune suppressive cells               by Adam Burrack, PhD Pancreatic islet transplants represent a potential cure for type 1 diabetes, but are limited both by resources – vanishingly few donor organs are available – and biology – we cannot prevent chronic transplant rejection. I recently described some of the […]

Saturday Morning Research Review – December 17, 2016

The double-edged sword of cancer immunotherapy and autoimmunity by Adam Burrack, PhD “Immune checkpoint” therapy is the current cutting edge to treat cancer. Since cancer is the mirror image of autoimmunity – in cancer we want to promote a response in the presence of strong local suppression, in autoimmunity we want to stop a response […]

Saturday Morning Research Review – December 10, 2016

A brief history of immune recognition and tolerance of pancreatic islet transplants by Adam Burrack, PhD We’ve not spent much space in this blogs series describing how pancreatic islet transplants are destroyed. In one of our first blog posts, I described Doug Melton’s work producing patient-specific beta cells, but haven’t gotten into the details of […]