Saturday Morning Research Review – November 26, 2016

Benefits and limitations of HbA1c as a measurement of T1D management                   by Adam Burrack, PhD Ever wonder how well hemoglobin A1c (HbA1c) reflects your diabetes management? I know I have. First, a little background on what this number represents and how it came to become the “gold standard” of diabetes management. Long story short, […]

Saturday Morning Research Review – November 19, 2016

Activity level improves T1D management by Adam Burrack, PhD A key pillar of YOUglycemia’s mission statement is that consistent aerobic exercise helps to manage type 1 diabetes. These benefits include enhanced sensitivity to injected insulin, improved carbohydrate metabolism, and the well-documented benefits of aerobic exercise for learning and memory formation summarized in this Runner’s World […]

Saturday Morning Research Review – November 12, 2016

Introducing the “exercise hormone” – irisin by Adam Burrack, PhD I have previously described the role of the signaling molecule IL-6 as the “exercise factor” in several posts to our blog. Briefly, IL-6 is normally thought of as a “pro-inflammatory” signal released during infections. But, during aerobic exercise our muscles produce this molecule. In this […]

Saturday Morning Research Review – November 5, 2016

Newly discovered connection between IL-6 and T1D onset by Adam Burrack, PhD Interleukins – the general term is cytokines – are like the hormones of the immune system: they can be produced by either cells of the immune system or infected tissue cells, and can influence the activation of immune cells and their movement throughout […]

Saturday Morning Research Review – October 29, 2016

Beta cell biology of GABA in inflammation and exercise by Adam Burrack, PhD Several blogs in our series have focused on the role of insulin-derived peptides as targets of autoreactive T cells in the destruction of beta cells leading to development of type 1 diabetes. In particular my descriptions of the research of George Eisenbarth […]

Saturday Morning Research Review – October 22, 2016

Recent studies of glucose control and autoimmunity in pets by Adam Burrack, PhD Last fall I profiled diabetic guide dogs, which have been gaining favor among people with type 1 diabetes (T1D) who live alone and/or are concerned about severe hypoglycemic episodes. Today I will describe several more recent reports detailing the development of diabetes […]

Saturday Morning Research Review – October 15, 2016

Potential “phenotypic signature” of T cells in pediatric-onset type 1 diabetes by Adam Burrack, PhD Predictive markers of T cell responses against beta cells are a highly sought clinical diagnostic. Analysis of a validated, limited, set of cell surface proteins on T cells collected from peripheral blood would facilitate “risk assessment” in people at-risk of […]

Saturday Morning Research Review – October 8, 2016

Beta cells work harder in response to high-fat diet before they increase mass or divide by Adam Burrack, PhD It has been a long-standing question in the beta cell biology field how beta cells respond to metabolic stress – or high demand for insulin production. The answer to this question is directly relevant to the […]

Saturday Morning Research Review – October 1, 2016

Report on Human Islet Research Network, May 2016 meeting                   by Adam Burrack, PhD I recently had the chance to attend the annual meeting of the human islet research network in Bethesda, Maryland. This is a group of researchers funded through the National Institutes of Health, specifically the NIDDK and the Special Diabetes Program. The human islet […]

Saturday Morning Research Review – September 24, 2016

Evidence for a direct relationship between impaired coxsackie B virus clearance and subsequent type 1 diabetes by Adam Burrack, PhD We return again today to the relationship between viral infection and subsequent autoimmunity. This will be a bit of a deep dive into theory and history of immunology, so grab your pipettes, turn on your […]