Glucagon dosing study provides starting point for thermostat-like clinical control of blood glucose levels by Adam Burrack, PhD As people with diabetes (PWD) we often focus, sometimes myopically, on insulin treatment to lower our blood glucose levels. While critical for the normal, thermostat-like regulation of blood sugar levels, insulin is half the story, at best. […]
Saturday Morning Research Review – March 19, 2016
Hybrid-insulin peptides are key clinically-relevant target of T cells by Adam Burrack, PhD We return to two familiar topics in our series: the ground-breaking research of Katie Haskins and Thomas Delong at the University of Colorado Immunology Department and clinical samples available through the St Vincent Institute in Melbourne, Australia. For many years – perhaps since […]
Saturday Morning Research Review – March 12, 2016
Unique benefits of resistance exercise to BG level management and the importance of a low glycemic index post-exercise meal by Adam Burrack, PhD Today we return to practical matters of blood glucose level management with exercise for the individual with type 1 diabetes (T1D). While YOUglycemia’s primary athletic pursuits are aerobic sports, there are many […]
Saturday Morning Research Review – March 5, 2016
The key role of dendritic cells in shaping the T cell response, as studied by Kristen Tarbell at NIH by Adam Burrack, PhD Why T cells of the immune system target beta cells in the pancreas for destruction is a complex problem with many partial answers. The answers to this question relate to genetics, the […]
Saturday Morning Research Review – February 27, 2016
Recent update: regulatory T cell add-back therapy by Adam Burrack, PhD Regular readers of this series will be aware that insulin-producing beta cells in the pancreas are destroyed by T cells of the immune system preceding a diagnosis of type 1 diabetes (T1D). Clinical treatment of T1D focuses on the replacement of insulin because virtually […]
Saturday Morning Research Review – February 13, 2016
Teasing apart the required components of the immune system for diabetes in mouse models by Adam Burrack, PhD Today’s topic will cut to the nitty-gritty of figuring out how type 1 diabetes (T1D) happens. Since we cannot do reductionist experiments in primates or humans – removing one component at a time and seeing whether each […]
Saturday Morning Research Review – February 6, 2016
Longitudinal study finds that physical activity decreases with duration of T1D by Adam Burrack, PhD YOUglycemia’s mission is to promote healthy levels of physical activity in people with diabetes. This is the point of our collaboration with the American Diabetes Association’s flag-ship event, the Tour de Cure. In short, we believe that the documented benefits […]
Saturday Morning Research Review – January 30, 2016
CD4 T cell responses against chromogranin A peptide: a critical interaction for disease onset, now defined at level of crystal structure by Adam Burrack, PhD Broad immune suppression or T cell depletion studies are not broadly applicable solutions to prevent type 1 diabetes (T1D) onset or rejection of transplanted pancreatic islets. These treatments would leave […]
Saturday Morning Research Review – January 23, 2016
Recent update: chronic nature of beta cell autoimmunity by Adam Burrack, PhD Regular readers of this series will be aware that the network of pancreatic organ donation, operated through the University of Florida and collaborating institutions and funded by the JDRF, has been a boon to research of type 1 diabetes (T1D) pathogenesis. Today I […]
Saturday Morning Research Review – January 16, 2016
Why does hypoglycemic unawareness happen? by Adam Burrack, PhD In a previous post, I described the ground-breaking work by James Shapiro and others on the “Edmonton protocol” for preventing T cell-mediated rejection of pancreatic islets following transplantation. In short, strong immune suppression is required to prevent destruction of islet transplants from one person to another […]