Saturday Morning Research Review – September 17, 2016

An important role for macrophage and T cell production of reactive oxygen species production in beta cell death by Adam Burrack, PhD Macrophages play a key role in diabetes onset in the mouse model of type 1 diabetes, the NOD mouse. Whether macrophages or T cells are the “final effector” of beta cell death is […]

Glacier National Park: A Road Trip, Diabetes Management Story

National Park road trip and hiking diabetes management with continuous glucose monitor by Adam Burrack, PhD I really, really enjoy hiking in the mountains – see previous post about Mount Kilimanjaro. Mountain hiking was probably my favorite recreational activity living in Colorado for 5 years for graduate school. This past Labor Day weekend, my wife […]

Saturday Morning Research Review – September 23, 2016

  Cathepsin-B as a Promoter of Brain Function by Daniel Schneider At this point in time, there is no lack of physiology research that shows the benefits of exercise. But that will not stop us from continuing to point out new and exciting research for our readers. Today we discuss a potential mediator of brain […]

Saturday Morning Research Review – August 27, 2016

A key connection between gut microbiome and experimentally-induced diabetes by Adam Burrack, PhD Readers of our series will be familiar with the concept of the gut microbiome. In short, this term refers to the observation that the number of bacteria in our intestines outnumbers the human cells of our bodies by a factor of 10-to-1. […]

Saturday Morning Research Review – August 20, 2016

Liver glycogen level determines counter-regulatory hormone response to low blood sugar levels by Adam Burrack, PhD Our readers – especially those with type 1 diabetes who have trained for and competed in races – will be aware: glucose is the primary source of fuel during exercise. In addition, you are probably aware that liver glycogen […]

Saturday Morning Research Review – August 6, 2016

Cardiorespiratory Fitness as a Predictor of Type 2 Diabetes By Daniel Schneider In case anyone was still not convinced, here’s another study that we can add to the long pile of reasons to exercise. In this longitudinal study (done over a long period of time), thousands of people took a stress test to test their fitness […]

Saturday Morning Research Review – July 30, 2016

The relationship of viral infection and autoimmunity by Adam Burrack, PhD Readers of our blog will be familiar with the concept of pancreas-tropic viruses accelerating beta cell destruction. The most extreme version of this concept is fulminant diabetes, which I have described previously. The general idea is that a viral infection in the pancreas, promotes […]

Saturday Morning Research Review – July 23, 2016

Reversion of beta cell autoimmunity and rate of progression from autoantibodies to T1D by Adam Burrack, PhD As I’ve described previously in our “science of type 1 diabetes” series, the TEDDY and DAISY studies are large cohort, longitudinal studies designed to test the genetic and environmental factors precipitating development of autoimmunity against beta cells and subsequent […]

Saturday Morning Research Review – July 16, 2016

Minimal intervals to improve insulin sensitivity and aerobic capacity              by Adam Burrack, PhD No time to exercise, you say? Can’t spare the time from your busy schedule but still want the key benefits of enhanced insulin sensitivity and enhanced mitochondrial density? Have you signed up for a 10K but haven’t been able to do […]

Saturday Morning Research Review – July 9, 2016

Nocturnal hypoglycemia is surprisingly common in children with type 1 diabetes by Adam Burrack, PhD As we have previously discussed, a major driving motivation behind the development of so-called closed-loop insulin pump and continuous glucose monitor systems is to avoid low blood sugars overnight. This problem, nocturnal hypoglycemia and potentially spending hours at a time […]